Calmodulin-Dependent Protein Kinase II 290-309 |
| Catalog No.GC31170 |
Calmodulin-Dependent Protein Kinase II 290-309 est un puissant antagoniste de CaMK avec une IC50 de 52 nM pour l'inhibition de Ca2+/calmodulin-dependent protein kinase II.
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Cas No.: 115044-69-4
Sample solution is provided at 25 µL, 10mM.
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Calmodulin-Dependent Protein Kinase II (290-309) is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II.
Peptide 290 to 309 is found to be a potent calmodulin antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase. Neither truncation from the amino terminus (peptide 296-309) nor extension in the carboxyl-terminal direction (peptide 294-319) markedly affects calmodulin binding, whereas shortening the peptide from the carboxyl terminus (peptide 290-302) or from both ends (peptide 295-304) results in the elimination of this activity[1].
[1]. Payne ME, et al. Calcium/calmodulin-dependent protein kinase II. Characterization of distinct calmodulin binding and inhibitory domains. J Biol Chem. 1988 May 25;263(15):7190-5.
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