CAY10465 |
| Catalog No.GC18824 |
CAY10465 est un agoniste AhR sélectif et de haute affinité, avec un Ki de 0,2 nM, et ne montre aucun effet sur le récepteur des œstrogènes (Ki \u003e 100 000 nM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 688348-33-6
Sample solution is provided at 25 µL, 10mM.
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CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM).
CAY 10465 (Compound 4i) is a selective and high-affinity AhR receptor agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM)[1]. CAY 10465 (0.01 nM-100 μM) reduces apolipoprotein A-I (apo A-I) levels in HepG2 cells, and inhibits the synthesis of the protein[2].
References:
[1]. de Medina P, et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem. 2005 Jan 13;48(1):287-91.
[2]. Naem E, et al. Inhibition of apolipoprotein A-I gene by the aryl hydrocarbon receptor: a potential mechanism for smoking-associated hypoalphalipoproteinemia. Life Sci. 2012 Jul 26;91(1-2):64-9.
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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