Accueil>>Signaling Pathways>> TGF-β / Smad Signaling>> TGF-β Receptor>>Chromenone 1

Chromenone 1

Catalog No.GC70882

Chromenone 1 est un puissant potentialisateur de protéine osseuse morphogénétique ostéogénique (BMP).

Products are for research use only. Not for human use. We do not sell to patients.

Chromenone 1 Chemical Structure

Cas No.: 1639929-29-5

Taille Prix Stock Qté
1 mg
117,00 $US
En stock
5 mg
270,00 $US
En stock
10 mg
401,00 $US
En stock
25 mg
682,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents
Chromenone 1 is a potent osteogenic bone morphogenetic protein (BMP) potentiator. Chromenone 1 exhibits a unique mode of action as it induces a pronounced, kinase-independent, negative TGFβ feedback that enhances nuclear BMP-Smad signaling outputs.

Chromenone 1 rescues DMH-1-induced cardiogenesis (IC50=0.2 μM) and efficiently stimulates BMP-dependent osteogenesis from C2C12 myoblasts[1].

References:
[1]. Wesseler F, et al. Probing Embryonic Development Enables the Discovery of Unique Small-Molecule Bone Morphogenetic Protein Potentiators. J Med Chem. 2022;65(5):3978-3990.

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Review for Chromenone 1

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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