Chst15-IN-1 |
| Catalog No.GC66472 |
Chst15-IN-1 est un puissant inhibiteur covalent réversible de Chst15. Chst15-IN-1 inhibe efficacement les niveaux de sulfatation de la chondroÏtine sulfate-E (CS-E) et d'autres glycosaminoglycanes (GAG) sulfotransférases étroitement apparentées. Chst15-IN-1, en tant qu'inhibiteur sélectif de la sulfotransférase, peut diminuer les effets inhibiteurs des protéoglycanes de sulfate de chondroÏtine (CSPG) et peut être utilisé pour la stimulation de la réparation neuronale.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2158198-77-5
Sample solution is provided at 25 µL, 10mM.
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Chst15-IN-1 is a potent reversible covalent Chst15 inhibitor. Chst15-IN-1 effectively inhibits chondroitin sulfate-E (CS-E) sulfation levels and other closely related glycosaminoglycans (GAG) sulfotransferases. Chst15-IN-1, as a selective sulfotransferase inhibitor, can diminish the inhibitory effects of chondroitin sulfate proteoglycans (CSPGs), and can be used for the stimulation of neuronal repair[1].
Chst15-IN-1 (25 μM; 24 hours; Neu7 astrocytes) is selective for sulfotransferases over the myriad of reactive cysteine-containing proteins. Chst15-IN-1 (10 and 25 μM; Neu7 astrocytes) shows a significant dose dependent decrease in cell-surface CS-E expression[1].
Chst15-IN-1 (3.0 mg/kg; i.v.) has a moderate clearance of 21 mL/min/kg, moderate volume of distribution of 0.97 L/kg, and short terminal half-life of 1.6 hours[1].
| Animal Model: | Rats |
| Dosage: | 3.0 mg/kg (Pharmacokinetic Analysis) |
| Administration: | I.v. |
| Result: | Had a moderate clearance of 21 mL/min/kg, moderate volume of distribution of 0.97 L/kg, and short terminal half-life of 1.6 h. |
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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