CK2 inhibitor 10 |
| Catalog No.GB40147 |
Potent and ATP-competitive inhibitor of protein kinase (CK2; IC50 values of 32 nM and 46 nM for CK2α and CK2α' respectively). At 0.30 μM, compound 10 exhibited a >50% inhibitory effect against 9 out of 70 other kinases besides CK2α and CK2α′, while at 30 nM >75% inhibition was observed for two other kinases (DYRK1B and FLT3) only. It exhibited potent cytotoxicity towards lung cancer cells A549, colorectal cancer cells HCT-116, and breast cancer cells MCF-7.
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Cas No.: 1361229-76-6
Sample solution is provided at 25 µL, 10mM.
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Potent and ATP-competitive inhibitor of protein kinase (CK2; IC50 values of 32 nM and 46 nM for CK2α and CK2α' respectively). At 0.30 μM, compound 10 exhibited a >50% inhibitory effect against 9 out of 70 other kinases besides CK2α and CK2α′, while at 30 nM >75% inhibition was observed for two other kinases (DYRK1B and FLT3) only. It exhibited potent cytotoxicity towards lung cancer cells A549, colorectal cancer cells HCT-116, and breast cancer cells MCF-7.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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