Curcumenol (Synonyms: (+)-Curcumenol) |
| Catalog No.GC41611 |
Le curcuménol ((+)-Curcumenol) est un puissant inhibiteur du CYP3A4 avec une IC50 de 12,6 μM, qui est l'un des constituants des plantes du genre médicinal important de Curcuma zedoaria, avec neuroprotection, anti-inflammatoire, antitumoral et activités hépatoprotectrices.
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Cas No.: 19431-84-6
Sample solution is provided at 25 µL, 10mM.
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Curcumenol ((+)-Curcumenol) is a potent CYP3A4 inhibitor with an IC50 of 12.6 μM, which is one of constituents in the plants of medicinally important genus of Curcuma zedoaria, with neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. Curcumenol ((+)-Curcumenol) suppresses Akt-mediated NF-κB activation and p38 MAPK signaling pathway in LPS-stimulated BV-2 microglial cells[1][2].
References:
[1]. Sun DX, et al. Inhibitory effects of curcumenol on human liver cytochrome P450 enzymes. Phytother Res. 2010 Aug;24(8):1213-6.
[2]. Lo JY, et al. Curcumenol isolated from Curcuma zedoaria suppresses Akt-mediated NF-κB activation and p38 MAPK signaling pathway in LPS-stimulated BV-2 microglial cells. Food Funct. 2015 Nov;6(11):3550-9.
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