DC07090 dihydrochloride |
| Catalog No.GC70549 |
DC07090 dihydrochloride est un inhibiteur de la protéase 3C de l'entérovirus humain 71 non peptidylique, faiblement toxique, puissant, réversible et compétitif, avec des valeurs d'IC50 et de ki de 21,72 µm et 23,29 µm, respectivement.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1158264-37-9
Sample solution is provided at 25 µL, 10mM.
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DC07090 dihydrochloride forms stable hydrogen-bonding interactions with the main chains of S128, G145, G164 and hydrophobic interactions with F25, L125, L127 and F170. DC07090 dihydrochloride (0.01~10 μM) shows micromolar potency against EV71 3Cpro. DC07090 dihydrochloride exhibits a highly inhibitory potency on EV71 replication with an EC50 value of 22.09 μM. DC07090 dihydrochloride inhibits CVA16 with an EC50 value of 27.76 μM[1].
References:
[1]. Ma GH, et al. Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening. Eur J Med Chem. 2016 Nov 29;124:981-991.
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