DC1-SMe |
| Catalog No.GC34190 |
DC1Sme, un dérivé de DC1, présente des valeurs IC50 de 22 h, 22 h, 32 h et 250 h pour les cellules cancéreuses Ramos, Namalwa, HL60/s et COLO 205, respectivement. DC1, un analogue de l'alkylateur d'ADN se liant au sillon mineur CC-1065, est une cytotoxine ADC. DC1 peut être utilisé dans la synthèse de conjugués anticorps-médicament pour le traitement ciblé du cancer.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 501666-85-9
Sample solution is provided at 25 µL, 10mM.
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DC1-Sme is an antibody conjugate of phosphate prodrug of cytotoxic DNA alkylators for the targeted treatment of cancer.
[1]. Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82.
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
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