Dehydroevodiamine (hydrochloride) |
| Catalog No.GC43405 |
Dehydroevodiamine is an alkaloid that has been isolated from E.
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Cas No.: 111664-82-5
Sample solution is provided at 25 µL, 10mM.
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Dehydroevodiamine is an alkaloid that has been isolated from E. rutaecarpa and has anti-inflammatory, antiarrhythmic, hypotensive, and anti-amnesic biological activities. It inhibits LPS-induced secretion of prostaglandin E2 in RAW 264.7 mouse macrophages when used at a concentration of 30 μM. Dehydroevodiamine (0.1-0.3 μM) reduces the upstroke velocity, action potential amplitude, and contractile force of electrically-stimulated primary human atrial trabeculae. In vivo, dehydroevodiamine (10 mg/kg) decreases mean arterial blood pressure (MAP) by approximately 30% in rats. Dehydroevodiamine (1.5 mg/kg) also inhibits amnesia induced by amyloid-β (25-35) and increases latency to step-through in a passive avoidance test in mice.
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)
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