Dihydromunduletone (Synonyms: DHM) |
| Catalog No.GC39375 |
La dihydromunduletone (DHM) est un dérivé roténoÏde et un antagoniste sélectif et puissant du récepteur couplé À la protéine G d'adhésion (aGPCR) (GPR56 et GPR114/ADGRG5) avec une CI 50 de 20,9 μM pour le GPR56, mais n'inhibe pas le GPR110 ni les GPCR de classe A[1 ].
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Cas No.: 674786-20-0
Sample solution is provided at 25 µL, 10mM.
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Dihydromunduletone (DHM) is a rotenoid derivative and a selective, potent adhesion G protein-coupled receptor (aGPCR) (GPR56 and GPR114/ADGRG5) antagonist with an IC 50 of 20.9 μM for GPR56, but not inhibit GPR110 or class A GPCRs[1].
[1]. Hannah M. Stoveken, et al. Dihydromunduletone Is a Small-Molecule Selective Adhesion G Protein-Coupled Receptor Antagonist. Mol Pharmacol. 2016 Sep; 90(3): 214-224.
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