Dioctatin A (hydrochloride) |
| Catalog No.GC90668 |
Un métabolite bactérien avec une activité inhibitrice de mycotoxines.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Dioctatin A is a bacterial metabolite that has been found in Streptomyces and has mycotoxin inhibitory activity.1 It inhibits the production of aflatoxin and norsolorinic acid, a biosynthetic precursor of aflatoxin, in A. parasiticus (IC50s = 4 and 0.8 µM, respectively) but does not inhibit mycelial growth of A. parasiticus when used at a concentration of 50 µM. Dioctatin A (50 µM) decreases the mRNA expression of genes encoding aflatoxin biosynthetic enzymes and increases the production of the fungal metabolite kojic acid in A. parasiticus. It inhibits the production of the mycotoxin sterigmatocystin in A. nidulans (IC50 = 0.3 µM) and the conidiation of A. parasiticus and A. nidulans when used at a concentration of 50 µM.
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