DK-AH 269 (Synonyms: Cilobradine) |
Catalog No.GC18503 |
La cilobradine est un bloqueur des canaux HCN ; un bloqueur de canal ouvert des canaux Ih neuronaux et des canaux If cardiaques associés.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 186097-54-1
Sample solution is provided at 25 µL, 10mM.
DK-AH 269 (Cilobradine) is an HCN Channel blocker; an open channel blocker of neuronal Ih and related cardiac If channels.
Target: HCN Channel blocker
DK-AH 269 is a HCN channel blocker that is about 3 times more potent than ZD7288. At a concentration of 10 μM, DK-AH 269 inhibits WT mHCN2 channel current by 86 ± 2% (n = 5). In contrast, I432A and A425G channel currents were only reduced by 14 ± 1% (n = 4) and 19 ± 2% (n = 8), respectively, by this concentration of DK-AH 269. The double mutant (I432A/A425G) channel was even less sensitive to 10 μM DK-AH 269 (8 ± 2% inhibition; n = 4).
References
[1]. Cheng L, et al. Molecular mapping of the binding site for a blocker of hyperpolarization-activated, cyclic nucleotide-modulated pacemaker channels. J Pharmacol Exp Ther. 2007 Sep;322(3):931-939.
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