DNQX disodium salt (Synonyms: 6,7-Dinitroquinoxaline-2,3-dione) |
| Catalog No.GC10275 |
Le sel disodique de DNQX (FG 9041), un dérivé de la quinoxaline, est un puissant antagoniste sélectif et compétitif des récepteurs du glutamate non NMDA (CI50 = 0,5, 2 et 40 μM pour les récepteurs AMPA, kaÏnate et NMDA, respectivement).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1312992-24-7
Sample solution is provided at 25 µL, 10mM.
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DNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors, respectively versus IC50 = 40 μM for NMDA receptors).[1],[2],[3] This compound has been used to specifically target AMPA and kainate receptor responses and thus differentiate from that of NMDA receptors. DNQX does not stimulate a robust long-term potentiation in the hippocampus.[4]
Reference:
[1]. Armstrong, N., and Gouaux, E. Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: Crystal structures of the GluR2 ligand binding core. Neuron 28(1), 165-181 (2000).
[2]. Honoré, T., Davies, S.N., Drejer, J., et al. Quinoxalinediones: Potent competitive non-NMDA glutamate receptor antagonists. Science 241(4866), 701-703 (1988).
[3]. Lee, S.H., Govindaiah, G., and Cox, C.L. Selective excitatory actions of DNQX and CNQX in rat thalamic neurons. J. Neurophysiol. 103(4), 1728-1734 (2010).
[4]. Muller, D., Joly, M., and Lynch, G. Contributions of quisqualate and NMDA receptors to the induction and expression of LTP. Science 242(4886), 1694-1697 (1988).
| Cas No. | 1312992-24-7 | SDF | |
| Synonymes | 6,7-Dinitroquinoxaline-2,3-dione | ||
| Chemical Name | sodium 6,7-dinitroquinoxaline-2,3-bis(olate) | ||
| Canonical SMILES | [O-][N+](C1=C(C=C(C(N=C2[O-])=C1)N=C2[O-])[N+]([O-])=O)=O.[Na+].[Na+] | ||
| Formula | C8H2N4O6Na2 | M.Wt | 296.1 |
| Solubility | 5mg/mL in DMSO, 12mg/mL in DMF | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.3772 mL | 16.8862 mL | 33.7724 mL |
| 5 mM | 0.6754 mL | 3.3772 mL | 6.7545 mL |
| 10 mM | 0.3377 mL | 1.6886 mL | 3.3772 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 1 reference(s) in Google Scholar.)
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