Eicosapentaenoic Acid 1,2,3,4,5-13C |
Catalog No.GC90364 |
Un standard interne pour la quantification de l'EPA
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
Eicosapentaenoic acid 1,2,3,4,5-13C (EPA 1,2,3,4,5-13C) is intended for use as an internal standard for the quantification of EPA by GC- or LC-MS. EPA is an ω-3, polyunsaturated fatty acid that has been found in fish oil.1 It inhibits RANKL-induced increases in TNF-α levels in RAW 264.7 cells when used at concentrations of 50 and 100 µM.2 EPA (65 pM) reduces thrombin-induced aggregation of, and increases thromboxane 3 (TXA3) levels in, platelets from isolated human platelet-rich plasma.3 It reduces RANKL-induced TGF-β receptor-associated protein 1 (TRAP1) stimulation of osteoclast differentiation in RAW 264.7 cells when used at concentrations of 50 and 100 µM and decreases RANKL-induced bone resorption in RAW 264.7 cells at 50 µM.2 EPA (50 µg/ml) decreases aspartate aminotransferase activity in dogs.4 It prevents reductions in brain perfusion and increases in cortical and striatal infarct volumes, as well as improves lateral coordination and posture, in a rat model of ischemia and reperfusion when administered at a dose of 100 mg/kg per day.5
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