ERDRP-0519 |
| Catalog No.GC64107 |
ERDRP-0519, un inhibiteur de la polymérase du virus de la rougeole (MeV) À petite molécule biodisponible par voie orale, prévient la maladie de la rougeole chez les singes écureuils (Saimiri sciureus).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1374006-96-8
Sample solution is provided at 25 µL, 10mM.
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ERDRP-0519, an orally bioavailable small-molecule Measles virus (MeV) polymerase inhibitor, prevents measles disease in squirrel monkeys (Saimiri sciureus). ERDRP-0519 inhibits morbilliviruses with nanomolar potency.[1][2][3].
ERDRP-0519 exhibits potency against a panel of Measles virus (MeV) isolates with EC50s of 0.07- 0.3 µM[1]. ERDRP-0519 exhibits potency against MeV and related pathogens of the Morbillivirus genus, such as canine distemper virus (CDV)[3].
A single-dose pharmacokinetic (PK) study is performed in squirrel monkeys by oral (intragastric) delivery of ERDRP-0519 (50 mg/kg) and blood sampling at seven predefined time points after dosing. Serum concentrations peak ~2 h post-administration (Cmax=3.27 µM)[3].
[1]. Wittwer K, et al. Small-molecule polymerase inhibitor protects non-human primates from measles and reduces shedding. Nat Commun. 2021 Sep 2;12(1):5233.
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