Firuglipel (Synonyms: DS-8500a) |
| Catalog No.GC31508 |
Firuglipel (DS-8500a) est un agoniste du GPR119 disponible par voie orale, puissant et sélectif.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1371591-51-3
Sample solution is provided at 25 µL, 10mM.
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Firuglipel (DS-8500a) is an orally available, potent and selective GPR119 agonist.
Firuglipel (DS-8500a) increases intracellular cAMP in a concentration-dependent manner in human, rat, and mouse GPR119-expressing Chinese hamster ovary (CHO)-K1 cells, with EC50 values of 51.5, 98.4, and 108.1 nM, respectively. DS-8500a has no effect on intracellular cAMP in pcDNA3.1/CHO-K1 cells[1].
Firuglipel (DS-8500a) (1-30 mg/kg) upregulates glucagon-like peptide-1 and enhances glucose-dependent insulin secretion and improves glucose homeostasis in type 2 diabetic rats[1].
[1]. Matsumoto K, et al. DS-8500a, an Orally Available G Protein-Coupled Receptor 119 Agonist, Upregulates Glucagon-Like Peptide-1 and Enhances Glucose-Dependent Insulin Secretion and Improves Glucose Homeostasis in Type 2 Diabetic Rats. J Pharmacol Exp Ther. 2018 Dec;367(3):509-517.
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