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Furin Inhibitor I (trifluoroacetate salt)

Catalog No.GC90077

Un inhibiteur de proprotéine convertase

Products are for research use only. Not for human use. We do not sell to patients.

Furin Inhibitor I (trifluoroacetate salt) Chemical Structure

Taille Prix Stock Qté
500 μg
131,00 $US
En stock
1 mg
221,00 $US
En stock
5 mg
1 028,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents

Furin is a proprotein convertase, converting precursor proteins to functional proteins within the Golgi/trans-Golgi secretory pathway. Furin inhibitor I is a selective, irreversible, and cell-permeable competitive inhibitor of proprotein convertases, including furin/SPC1 (Ki = ~1 nM), SPC2/PC2 (Ki = 0.36 nM), SPC3/PC1/PC3 (Ki = 2.0 nM), SPC4/PACE4 (Ki = 3.6 nM), SPC6/PC5/PC6, and SPC7/LPC/PC7/PC8 (Ki = 0.12 nM).1,2 Because furin activates viral glycoproteins, this inhibitor is a useful antiviral agent.3 In addition, it inhibits furin-dependent pro-MMP-2 activation in mononuclear inflammatory cells.4

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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