Fz7-21 TFA (Synonyms: Ac-LPSDDLEFWCHVMY-NH2 TFA) |
| Catalog No.GC39383 |
Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) TFA est un puissant antagoniste peptidique des récepteurs FZD7, se lie sélectivement À la sous-classe FZD7 CRD et modifie la conformation du CRD et l'architecture de son sillon de liaison aux lipides. Les valeurs EC50 sont de 58 et 34 nM pour le FZD7 CRD humain et murin, respectivement. Fz7-21 TFA altère la fonction de FZD7 dans la signalisation Wnt-β-caténine et la fonction des cellules souches dans les organoÏdes intestinaux.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Fz7-21 TFA ((Ac)-LPSDDLEFWCHVMY-NH2 TFA), a peptide antagonist of Frizzled 7 (FZD 7) receptors, selectively binds to FZD7 CRD subclass. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 impairs Wnt/β-catenin signaling in HEK293 cells stimulated with exogenous WNT3A (IC50=100 nM) or transfected with a construct expressing WNT3A or WNT1. Fz7-21 also blocks WNT3A-mediated stabilization of β-catenin in mouse L cells (IC50=50 nM)[1].
[1]. Nile AH, et al. Publisher Correction: A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells. Nat Chem Biol. 2018 Sep;14(9):902.
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