GAK inhibitor 49 |
| Catalog No.GC60863 |
L'inhibiteur de GAK 49 est un puissant inhibiteur de la kinase associée À la cycline G (GAK) compétitif pour l'ATP et hautement sélectif avec un Ki de 0,54 nM et une cellule IC50 de 56 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 319492-82-5
Sample solution is provided at 25 µL, 10mM.
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GAK inhibitor 49 is a potent, ATP-competitive and highly selective cyclin G associated kinase (GAK) inhibitor with a Ki of 0.54 nM and a cell IC50 of 56 nM. GAK inhibitor 49 also shows binding to RIPK2[1].
GAK inhibitor 49 (compound 49) shows a weak inhibitory effect on AAK1, BMP2K and STK16, with IC50s of 28, 63 and >100μM, respectively[1].
[1]. Asquith CRM, et al. Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase. ChemMedChem. 2018;13(1):48-66.
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