Garcinoic Acid (Synonyms: δ-Garcinoic Acid, δ-trans-Tocotrienoloic Acid) |
| Catalog No.GC46150 |
L'acide garcinoÏque est l'analogue de la vitamine E extrait des graines de Garcinia Kola. L'acide garcinoÏque montre un effet antiprolifératif marqué sur les cellules cancéreuses du gliome C6.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 91893-83-3
Sample solution is provided at 25 µL, 10mM.
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Garcinoic acid is a derivative of vitamin E originally isolated from C. grandiflora.1 It inhibits IL-1β-induced microsomal prostaglandin E2 synthase-1 (mPGES-1) activity in A549 cells when used at concentrations of 1 and 10 μM.2 It has higher antioxidant activity relative to (±)-α-tocopherol in a cell-free assay when used at a concentration of 0.15 mM.3
|1. Monache, F.D., Marta, M., Mac-Quhae, M.M., et al. Two new tocotrienoloic acids from the fruits of Clusia grandiflora Splith. Gazz. Chim. Ital. 114(3-4), 135-137 (1984).|2. Alsabil, K., Suor-Cherer, S., Koeberle, A., et al. Semisynthetic and natural garcinoic acid isoforms as new mPGES-1 inhibitors. Planta Med. 82(11-12), 1110-1116 (2016).|3. Terashima, K., Takaya, Y., and Niwa, M. Powerful antioxidative agents based on garcinoic acid from Garcinia kola. Bioorg. Med. Chem. 10(5), 1619-1625 (2002).
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