6-Thioinosine |
Catalog No.GC35171 |
La 6-thioinosine (6TI) est un antimétabolite purique, agit comme un agent anti-adipogenèse, régule à la baisse les niveaux d'ARNm de PPAR γ et C/EBPα, ainsi que la protéine cible PPAR γ telle que LPL, CD36, aP2 et LXRα.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 574-25-4
Sample solution is provided at 25 µL, 10mM.
6-?Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent, downregulates mRNA levels of PPAR γ and C/EBPα, as well as PPAR γ target protein such as LPL, CD36, aP2, and LXRα[1][2].
[1]. Lee J, et al. Anti-adipogenesis by 6-thioinosine is mediated by downregulation of PPAR gamma through JNK-dependent upregulation of iNOS. Cell Mol Life Sci. 2010 Feb;67(3):467-81. [2]. Neubert D, et al. Interference of 6-mercaptopurine riboside, 6-methylmercaptopurine riboside and azathioprine with the morphogenetic differentiation of mouse extremities in vivo and in organ culture. Naunyn Schmiedebergs Arch Pharmacol. 1977 Jun;298(2):93-105.
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