7-Epi 10-desacetyl paclitaxel (Synonyms: 10-Deacetyl-7-epitaxol, 10-Deacetyl-7-epi-paclitaxel, 10-Deacetyl-7-epipaclitaxel, 10-Desacetyl-7-epi-taxol, 10-Desacetyl-7-epipaclitaxel, 7-epi-10-deacetyl Paclitaxel, Ormosin VI) |
| Catalog No.GC35187 |
Le 7-épi 10-désacétyl paclitaxel (7-épi-10-désacétyltaxol), un dérivé du taxol, présente une cytotoxicité contre les cellules HeLa avec une IC50 de 85 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 78454-17-8
Sample solution is provided at 25 µL, 10mM.
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7-Epi 10-desacetyl paclitaxel (7-epi-10-deacetyltaxol), a taxol derivative, exhibits cytotoxicity against HeLa cells with an IC50 of 85 μM[1][2].
[1]. Fungal 7-epi-10-deacetyltaxol produced by an endophytic Pestalotiopsis microspora induces apoptosis in human hepatocellular carcinoma cell line (HepG2). [2]. Dang PH, et al.α-Glucosidase Inhibitory and Cytotoxic Taxane Diterpenoids from the Stem Bark of Taxus wallichiana. J Nat Prod. 2017 Apr 28;80(4):1087-1095.
| Cas No. | 78454-17-8 | SDF | |
| Synonymes | 10-Deacetyl-7-epitaxol, 10-Deacetyl-7-epi-paclitaxel, 10-Deacetyl-7-epipaclitaxel, 10-Desacetyl-7-epi-taxol, 10-Desacetyl-7-epipaclitaxel, 7-epi-10-deacetyl Paclitaxel, Ormosin VI | ||
| Canonical SMILES | O=C(N[C@@H](C1=CC=CC=C1)[C@@H](O)C(O[C@H]2C[C@@](O)([C@@H](OC(C3=CC=CC=C3)=O)[C@@]4([H])[C@@]5(C)[C@H](O)C[C@]6([H])[C@@]4(OC(C)=O)CO6)C(C)(C)C([C@@H](O)C5=O)=C2C)=O)C7=CC=CC=C7 | ||
| Formula | C45H49NO13 | M.Wt | 811.87 |
| Solubility | Soluble in DMSO | Storage | 4°C, protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.2317 mL | 6.1586 mL | 12.3172 mL |
| 5 mM | 0.2463 mL | 1.2317 mL | 2.4634 mL |
| 10 mM | 0.1232 mL | 0.6159 mL | 1.2317 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)
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