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Kalii Dehydrographolidi Succinas

Catalog No.GC36381

Kalii Dehydrographolidi Succinas (succinate de déhydroandrographolide de potassium), extrait de la phytothérapie Andrographis paniculata (Burm f) Nees, est largement utilisé pour le traitement de la pneumonie virale et des infections virales des voies respiratoires supérieures en raison de son effet immunostimulant, anti-infectieux et anti-inflammatoire. 1].

Products are for research use only. Not for human use. We do not sell to patients.

Kalii Dehydrographolidi Succinas Chemical Structure

Cas No.: 76958-99-1

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Sample solution is provided at 25 µL, 10mM.

Description of Kalii Dehydrographolidi Succinas

Kalii Dehydrographolidi Succinas (Potassium dehydroandrographolide succinate), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, is widely used for the treatment of viral pneumonia and viral upper respiratory tract infections because of its immunostimulatory, anti-infective and anti-inflammatory effect[1][2].

[1]. Chen Q, et al. Pharmacokinetics and tolerance of dehydroandrographolide succinate injection after intravenousadministration in healthy Chinese volunteers. Acta Pharmacol Sin. 2012 Oct;33(10):1332-6. [2]. Xiaomeng Z, et al. Potassium dehydroandrographolide succinate injection for treat- ment of infantile pneumonia: a systematic review and Meta-analysis. J Tradit Chin Med. 2015 Apr;35(2):125-33.

Chemical Properties of Kalii Dehydrographolidi Succinas

Cas No. 76958-99-1 SDF
Canonical SMILES C[C@]1([C@@H]2/C=C/C3=CCOC3=O)[C@@](CCC2=C)([H])[C@@](C)([C@H](OC(CCC(O)=O)=O)CC1)COC(CCC(O)=O)=O.[K]
Formula C28H36KO10 M.Wt 571.68
Solubility DMSO: 5 mg/mL (8.76 mM) Storage 4°C, protect from light, stored under nitrogen
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Kalii Dehydrographolidi Succinas

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1 mg 5 mg 10 mg
1 mM 1.7492 mL 8.7462 mL 17.4923 mL
5 mM 0.3498 mL 1.7492 mL 3.4985 mL
10 mM 0.1749 mL 0.8746 mL 1.7492 mL
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In vivo Formulation Calculator (Clear solution) of Kalii Dehydrographolidi Succinas

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Review for Kalii Dehydrographolidi Succinas

Average Rating: 5 ★★★★★ (Based on Reviews and 26 reference(s) in Google Scholar.)

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