MD2-TLR4-IN-1 |
Catalog No.GC36578 |
MD2-TLR4-IN-1 (composé 22m) est un inhibiteur du complexe protéine de différenciation myéloÏde 2/récepteur de type péage 4 (MD2-TLR4), inhibant l'expression induite par les lipopolysaccharides (LPS) du facteur de nécrose tumorale alpha (TNF-α) et l'interleukine-6 (IL-6) dans les macrophages avec des valeurs IC50 de 0,89 μM et 0,53 μM, respectivement .
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2249801-12-3
Sample solution is provided at 25 µL, 10mM.
MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively[1]. MD2-TLR4[1].
[1]. Liu Z, et al. Discovery of 3-(Indol-5-yl)-indazole Derivatives as Novel Myeloid Differentiation Protein 2/Toll-like Receptor 4 Antagonists for Treatment of Acute Lung Injury. J Med Chem. 2019 Jun 13;62(11):5453-5469.
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