ML367 |
| Catalog No.GC36630 |
ML367 est un puissant inhibiteur de la stabilisation de la protéine 5 contenant le domaine AAA de la famille ATPase (ATAD5), agit comme une molécule sonde qui a une faible activité inhibitrice micromolaire. ML367 bloque les voies de réparation de l'ADN, supprime les réponses générales aux dommages À l'ADN, y compris la phosphorylation de RPA32 et la phosphorylation de CHK1 en réponse À l'irradiation UV.
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Cas No.: 381168-77-0
Sample solution is provided at 25 µL, 10mM.
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ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization, acts as a probe molecule that has low micromolar inhibitory activity. ML367 blocks DNA repair pathways, suppresses general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation[1]. ATAD5[1]
ML367 (0-40 μM, 16 hours) inhibits FLAG-ATAD5 stabilization in HEK293T cells in the presence or absence of 20 μM 5-FUrd[1]. Western Blot Analysis[1] Cell Line: HEK293T cells
[1]. Rohde JM, et al. Discovery of ML367, inhibitor of ATAD5 stabilization. Probe Reports from the NIH Molecular Libraries Program.
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