MMAF-OMe (Synonyms: Monomethyl auristatin F methyl ester) |
| Catalog No.GC36634 |
Le MMAF-Ome, un agent antitubuline, est également une cytotoxine ADC. MMAF-Ome inhibe plusieurs lignées cellulaires tumorales avec des IC50 de 0,056 nM, 0,166 nM, 0,183 nM et 0,449 nM pour les lignées cellulaires MDAMB435/5T4, MDAMB361DYT2, MDAMB468 et Raji (5T4-), respectivement.
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Cas No.: 863971-12-4
Sample solution is provided at 25 µL, 10mM.
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MMAF-Ome belongs to ADC, and inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively.
2.5F-Fc and 2.5F-Fc-MMAF have similar IC50 values (6.9±1.1 vs. 8.3±1.3 nM, respectively), indicating that MMAF conjugation has negligible impact on integrin-binding affinity[1].
[1]. Currier NV, et al. Targeted Drug Delivery with an Integrin-Binding Knottin-Fc-MMAF Conjugate Produced by Cell-Free Protein Synthesis. Mol Cancer Ther. 2016 Jun;15(6):1291-300.
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