Paricalcitol-D6 |
Catalog No.GC36854 |
Paricalcitol-d6 est le deutérium marqué Paricalcitol.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2070009-67-3
Sample solution is provided at 25 µL, 10mM.
Paricalcitol-D6 is the deuterated form of Paricalcitol(Zemplar), which is a drug used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure. IC50 value:Target: Vd analogChemically, it is 19-nor-1,25-(OH)2-vitamin D2 or 19-nor-1,25-dihydroxyvitamin D2, being an analog of 1,25-dihydroxyergocalciferol, the active form of vitamin D2.
[1]. Martinez-Moreno JM, Mu•oz-Casta•eda JR, Herencia C, Montes de Oca A, Estepa JC, Canalejo R, Rodriguez-Ortiz ME, Perez-Martinez P, Aguilera-Tejero E, Canalejo A, Rodriguez M, Almaden Y.In vascular smooth muscle cells paricalcitol prevents phosphate-induced Wnt/beta-catenin activation.Am J Physiol Renal Physiol. 2012 Aug 8. [2]. Ari E, Kedrah AE, Alahdab Y, Bulut G, Eren Z, Baytekin O, Odabasi D.Antioxidant and renoprotective effects of paricalcitol on experimental contrast-induced nephropathy model.Br J Radiol. 2012 Aug;85(1016):1038-43. [3]. Meems LM, Cannon MV, Mahmud H, Voors AA, van Gilst WH, SilljÉ HH, Ruifrok WP, de Boer RA.The vitamin D receptor activator paricalcitol prevents fibrosis and diastolic dysfunction in a murine model of pressure overload.J Steroid Biochem Mol Biol. 2012 Jul 16;132(3-5):282-289. [4]. Blanco-GarcÍa R, Bravo-LÓpez JJ, Moreiras-Plaza M, NÁjera-de la Garza W, Cossio-Annibar C, Beato-Coo L, RodrÍguez-Goyanes G.Microalbuminuria, another use for paricalcitol• Our experience in advanced chronic kidney disease.Nefrologia. 2012 May 14;32(3):401-2. doi: 10.3265/Nefrologia.pre2012.Feb.11378. [5]. Piao SG, Song JC, Lim SW, Chung BH, Choi BS, Yang CW.Protective effect of paricalcitol on cyclosporine-induced renal injury in rats.Transplant Proc. 2012 Apr;44(3):642-5.
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