Accueil>>Signaling Pathways>> Vitamin D Related>> VD/VDR>>Paricalcitol-D6

Paricalcitol-D6

Catalog No.GC36854

Paricalcitol-d6 est le deutérium marqué Paricalcitol.

Products are for research use only. Not for human use. We do not sell to patients.

Paricalcitol-D6 Chemical Structure

Cas No.: 2070009-67-3

Taille Prix Stock Qté
1mg
432,00 $US
En stock
5mg
2 069,00 $US
En stock
10mg
3 448,00 $US
En stock

Tel:(909) 407-4943 Email: sales@glpbio.com


Avis des clients

Based on customer reviews.

  • GlpBio Citations

    GlpBio Citations
  • Bioactive Compounds Premium Provider

    Bioactive Compounds Premium Provider

Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

Paricalcitol-D6 is the deuterated form of Paricalcitol(Zemplar), which is a drug used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure. IC50 value:Target: Vd analogChemically, it is 19-nor-1,25-(OH)2-vitamin D2 or 19-nor-1,25-dihydroxyvitamin D2, being an analog of 1,25-dihydroxyergocalciferol, the active form of vitamin D2.

[1]. Martinez-Moreno JM, Mu•oz-Casta•eda JR, Herencia C, Montes de Oca A, Estepa JC, Canalejo R, Rodriguez-Ortiz ME, Perez-Martinez P, Aguilera-Tejero E, Canalejo A, Rodriguez M, Almaden Y.In vascular smooth muscle cells paricalcitol prevents phosphate-induced Wnt/beta-catenin activation.Am J Physiol Renal Physiol. 2012 Aug 8. [2]. Ari E, Kedrah AE, Alahdab Y, Bulut G, Eren Z, Baytekin O, Odabasi D.Antioxidant and renoprotective effects of paricalcitol on experimental contrast-induced nephropathy model.Br J Radiol. 2012 Aug;85(1016):1038-43. [3]. Meems LM, Cannon MV, Mahmud H, Voors AA, van Gilst WH, SilljÉ HH, Ruifrok WP, de Boer RA.The vitamin D receptor activator paricalcitol prevents fibrosis and diastolic dysfunction in a murine model of pressure overload.J Steroid Biochem Mol Biol. 2012 Jul 16;132(3-5):282-289. [4]. Blanco-GarcÍa R, Bravo-LÓpez JJ, Moreiras-Plaza M, NÁjera-de la Garza W, Cossio-Annibar C, Beato-Coo L, RodrÍguez-Goyanes G.Microalbuminuria, another use for paricalcitol• Our experience in advanced chronic kidney disease.Nefrologia. 2012 May 14;32(3):401-2. doi: 10.3265/Nefrologia.pre2012.Feb.11378. [5]. Piao SG, Song JC, Lim SW, Chung BH, Choi BS, Yang CW.Protective effect of paricalcitol on cyclosporine-induced renal injury in rats.Transplant Proc. 2012 Apr;44(3):642-5.

Avis

Review for Paricalcitol-D6

Average Rating: 5 ★★★★★ (Based on Reviews and 24 reference(s) in Google Scholar.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%
Review for Paricalcitol-D6

GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.

Required fields are marked with *

You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.