TH287 hydrochloride |
| Catalog No.GC37775 |
Le chlorhydrate de TH287 est un inhibiteur puissant et sélectif de MTH1, avec une IC50 de 0,8 nM. Le chlorhydrate de TH287 est hautement sélectif vis-À-vis de MTH1, sans inhibition pertinente de MTH2, NUDT5, NUDT12, NUDT14, NUDT16, dCTPase, dUTPase et ITPA À 100 μM. Le chlorhydrate de TH287 pourrait agir comme agent chimiothérapeutique pour la recherche sur le cancer.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1638211-05-8
Sample solution is provided at 25 µL, 10mM.
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TH287 hydrochloride is a potent inhibitor of MTH1 (NUDT1) with an IC50 value of 0.8 nM, less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.IC50 value: 0.8 nM [1]Target: MTH1 inhibitorTH287 is considered a new target for cancer therapy. TH287 is highly selective towards MTH1, with no relevant inhibition of other members of the nudix protein family. TH287 has been shown to selectively kill a variety of cancer cell lines, but is rapidly metablized, so not as useful for in vivo studies.
[1]. Gad H, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014 Apr 10;508(7495):215-21.
Average Rating: 5 (Based on Reviews and 24 reference(s) in Google Scholar.)
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