Tubulysin |
| Catalog No.GC37835 |
La famille des métabolites secondaires de la tubulysine est isolée À l'origine des myxobactéries Archangium geophyra et Angiococcus disciformis. Ces composés sont de puissants agents de déstabilisation des microtubules avec des valeurs IC50 dans la gamme picomolaire contre de nombreuses lignées cellulaires cancéreuses, y compris celles ayant des propriétés multirésistantes. Les tubulysines ont une utilité thérapeutique limitée en raison d'une toxicité sévère, de sorte que les tubulysines sont des candidats idéaux pour être incorporées dans le système d'administration de conjugués de médicaments moléculaires (SMDC).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1943604-24-7
Sample solution is provided at 25 µL, 10mM.
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Tubulysin family of secondary metabolites are originally isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. These compounds are potent microtubule destabilizing agents with IC50 values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties. Tubulysins have limited therapeutic utility due to severe toxicity, so Tubulysins are ideal candidates to be incorporated into molecule drug conjugate (SMDC) delivery system[1].
[1]. Leamon CP, et al. Prostate-Specific Membrane Antigen-Specific Antitumor Activity of a Self-Immolative Tubulysin Conjugate. Bioconjug Chem. 2019 Jun 19;30(6):1805-1813.
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