XY101 |
| Catalog No.GC37944 |
XY101 est un agoniste inverse RORγ puissant, sélectif, métaboliquement stable et disponible par voie orale avec une IC50 de 30 nM et un Kd de 380 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2349368-16-5
Sample solution is provided at 25 µL, 10mM.
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XY101 is a potent, selective, metabolically stable and orally available RORγ inverse agonist with an IC50 of 30 nM and a Kd of 380 nM[1]. IC50: 30 nM (RORγ)[1]Kd: 380 nM (RORγ)[1]
XY101 potently inhibits cell growth, colony formation, and the expression of androgen receptor (AR), AR-V7 and prostate-specific antigen (PSA)[1].
XY101 exhibits significant antitumor activities during the treatment period with tumor growth inhibition and is well tolerated without obvious body weight loss[1].
[1]. Zhang Y, et al. Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable RORγ Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer. J Med Chem. 2019 May 9;62(9):4716-4730.
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
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