Demethylwedelolactone (Synonyms: DWL, Norwedelolactone, 1,3,8,9-Tetrahydroxycoumestan) |
| Catalog No.GC38576 |
La déméthylwedelolactone est un coumestan naturel isolé d'Eclipta alba. La déméthylwedelolactone est un puissant inhibiteur de la trypsine avec une CI50 de 3,0 μM. La déméthylwedelolactone supprime la motilité cellulaire et l'invasion cellulaire des cellules cancéreuses du sein.
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Cas No.: 6468-55-9
Sample solution is provided at 25 µL, 10mM.
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Demethylwedelolactone is a naturally occurring coumestan isolated from Eclipta alba. Demethylwedelolactone is a potent trypsin inhibitor with an IC50 of 3.0 μM. Demethylwedelolactone suppresses cell motility and cell invasion of breast cancer cell[1][2].
[1]. Syed SD, et al. Trypsin inhibitory effect of wedelolactone and demethylwedelolactone. Phytother Res. 2003 Apr;17(4):420-1. [2]. Lee YJ, et al. Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice. Eur J Med Chem. 2012 Oct;56:361-7.
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