N1-Acetylspermidine (hydrochloride) (Synonyms: N1-AcSPD) |
Catalog No.GC45518 |
La N1-acétylspermidine (chlorhydrate) est un dérivé acétylé de la polyamine. La N1-acétylspermine est le substrat de la polyamine oxydase (PAO). La N1-acétylspermidine (chlorhydrate) élève sélectivement son niveau dans les adénocarcinomes colorectaux humains. La N1-acétylspermidine montre une efficacité de clivage au niveau des sites apuriniques de l'ADN.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 34450-16-3
Sample solution is provided at 25 µL, 10mM.
N1-Acetylspermidine is an acetyl derivative of spermidine that acts as a substrate for polyamine oxidase (PAO).1 In peroxisomes, PAO oxidizes N1-acetylspermidine to 3-acetamidopropanal and putrescine, a positively charged polyamine that binds DNA and is involved in various cellular processes including cell division, differentiation, and membrane function.2,3,4,5 N1-Acetylspermidine has been used to examine the interaction between DNA and polyamines during the cleavage of phosphodiester bonds at apurinic/apyrimidinic sites in DNA.6
References
1. Takao, K., Sugita, Y., and Shirahata, A. Assay of N1-acetylpolyamine oxidase activity with N1,N11-didansylnorspermine as the substrate by ion-pair reversed phase high performance liquid chromatography. Biological and Pharmaceutical Bullentin 33(7), 1089-1094 (2010).
2. Gawandi, V., and Fitzpatrick, P.F. The synthesis of deuterium-labeled spermine, N1-acetylspermine and N1-acetylspermidine. Journal of Labelled Compounds and Radiopharmaceuticals 50(7), 666-670 (2007).
3. Gill, S.S., and Tuteja, N. Polyamines and abiotic stress tolerance in plants. Plant Signal. Behav. 5(1), 26-33 (2010).
4. Prunotto, M., Compagnone, A., Bruschi, M., et al. Endocellular polyamine availability modulates epithelial-to-mesenchymal transtition and unfolded protein response in MDCK cells. Lab Invest. 90(6), 929-939 (2010).
5. Babbar, N., Ignatenko, N.A., Casero, R.A., Jr., et al. Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer. The Journal of Biological Chemisty 278(48), 47762-47775 (2003).
6. Haukanes, B.I., Szajko, K., and Helland, D.E. Action of spermidine, N1-acetylspermidine, and N8-acetylspermidine at apurinic sites in DNA. FEBS Letters 269(2), 389-393 (1990).
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