Sciadopitysin (Synonyms: NSC 45108) |
Catalog No.GC45561 |
La sciadopitysine est un type de biflavonoÏdes présents dans les feuilles de ginkgo biloba.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 521-34-6
Sample solution is provided at 25 µL, 10mM.
Sciadopitysin is a biflavonoid originally isolated from G. biloba and has diverse biological activities.1,2,3,4 It reduces cytotoxicity induced by amyloid-β (1-42) in PC12 cells (EC50 = 9.84 μM).2 Sciadopitysin (0.1-10 μM) decreases methylglyoxal-induced insulin secretion, production of reactive oxygen species (ROS), cardiolipin peroxidation, and cytotoxicity in RIN-m5F pancreatic β-cells.3 It inhibits P-glycoprotein (P-gp; IC50 = 53.42 μM) and increases cellular toxicity of paraquat and paclitaxel in MDR1-MDCKII cells.5 Sciadopitysin inhibits RANKL-induced mRNA expression of the osteoclast-specific genes CTSK, TRAP, and MMP-9, activation of NF-κB, and osteoclastogenesis in a mouse model of LPS-induced bone loss.4
References
1. Brian•on-Scheid, F., Lobstein-Guth, A., and Anton, R. HPLC separation and quantitative determination of biflavones in leaves from ginkgo biloba. Planta Med. 49(12), 204-207 (1983).
2. Sasaki, H., Kitoh, Y., Tsukada, M., et al. Inhibitory activities of biflavonoids against amyloid-β peptide 42 cytotoxicity in PC-12 cells. Bioorg. Med. Chem. 25(14), 2831-2833 (2015).
3. Suh, K.S., Chon, S., and Choi, E.M. The protective effects of sciadopitysin against methylglyoxal-induced cytotoxicity in cultured pancreatic β-cells. J. Appl. Toxicol. 38(8), 1104-1111 (2018).
4. Cao, J., Lu, Q., Liu, N., et al. Sciadopitysin suppresses RANKL-mediated osteoclastogenesis and prevents bone loss in LPS-treated mice. Int. Immunopharmacol. 49, 109-117 (2017).
5. Bai, J., Zhao, S., Fan, X., et al. Inhibitory effects of flavonoids on P-glycoprotein in vitro and in vivo: Food/herb-drug interactions and structure-activity relationships. Toxicol. Appl. Pharmacol. 369, 49-59 (2019).
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