Gentisein (Synonyms: NSC 329491) |
Catalog No.GC49106 |
La gentiseine (NSC 329491), le principal métabolite de la mangiférine, présente l'inhibition de l'absorption de la sérotonine la plus puissante avec une valeur IC50 de 4,7 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 529-49-7
Sample solution is provided at 25 µL, 10mM.
Gentisein is a xanthone that has been found in H. annulatum and has diverse biological activities.1,2,3 It scavenges DPPH radicals and inhibits the activity of α-glucosidase in cell-free assays (IC50s = 23.3 and 14.7 µM, respectively).1,2 Gentisein is cytotoxic against K562 chronic multiple leukemia cells, drug-sensitive HL-60 acute promyelocyte leukemia cells, and multidrug-resistant HL-60/DOX cells (IC50s = 102, 90.9, and 88.3 µM, respectively).3
1.Zhong, F.-F., Chen, Y., and Yang, G.-Z.Prenylated xanthones from the bark of Garcinia xanthochymus and their 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activitiesMolecules15(10)7438-7449(2008) 2.Liu, Y., Zou, L., Ma, L., et al.Synthesis and pharmacological activities of xanthone derivatives as α-glucosidase inhibitorsBioorg. Med. Chem.14(16)5683-5690(2006) 3.Biljali, S., Nedialkov, P., Zheleva-Dimitrova, D., et al.Cytotoxic effects and multidrug resistance modulation by five benzophenones and a xanthone Isolated from Hypericum annulatum Moris SUBSP. AnnulatumBiotechnol. Biotechnol. Equip.27(1)3561-3568(2014)
Average Rating: 5
(Based on Reviews and 11 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *