5-Methoxy-3-(1，2，3，6-tetrahydropyridin-4-yl)-1H-indole succinate(2:1) |
| Catalog No.GF21120 |
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 107008-28-6
Sample solution is provided at 25 µL, 10mM.
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RU 24969 succinate (30 nM-1 渭M) dose-dependently inhibits K+ evoked efflux of tritium and shows a pD2 value of 7.45 for the maximum effect at 1 渭M[1].
RU 24969 succinate (1 and 3 mg/kg; s.c., once) potentiates addictive agent-induced effects[2].
RU 24969 succinate (0.03-3.0 mg/kg; s.c., once) dose-dependently decreases water consumption in water deprived rats[4].
[1]. Middlemiss DN. The putative 5-HT1 receptor agonist, RU 24969, inhibits the efflux of 5-hydroxytryptamine from rat frontal cortex slices by stimulation of the 5-HT autoreceptor. J Pharm Pharmacol. 1985 Jun;37(6):434-7.
[2]. Parsons LH, et al. RU 24969, a 5-HT1B/1A receptor agonist, potentiates cocaine-induced increases in nucleus accumbens dopamine. Synapse. 1999 May;32(2):132-5.
[3]. Peroutka SJ. Pharmacological differentiation and characterization of 5-HT1A, 5-HT1B, and 5-HT1C binding sites in rat frontal cortex. J Neurochem. 1986 Aug;47(2):529-40.
[4]. Aronsen D, et al. RU 24969-produced adipsia and hyperlocomotion: differential role of 5HT 1A and 5HT 1B receptor mechanisms. Pharmacol Biochem Behav. 2014 Sep;124:1-4.
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