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GNE 0723

Catalog No.GC31270

GNE 0723 est un modulateur allostérique positif perméable au cerveau du NMDAR, avec une EC50 de 21 nM pour GluN2A, 7,4 et 6,2 μM pour GluN2C et GluN2D, respectivement.

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GNE 0723 Chemical Structure

Cas No.: 1883518-31-7

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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 1 publications

Description Chemical Properties Product Documents Related Products

GNE 0723 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 21 nM for GluN2A, 7.4 and 6.2 μM for GluN2C and GluN2D, respectively.

GNE 0723 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 21 nM for GluN2A, 7.4 and 6.2 μM for GluN2C and GluN2D, respectively[1].

[1]. Villemure E, et al. GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile. ACS Med Chem Lett. 2016 Oct 31;8(1):84-89.

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