GSK2879552 dihydrochloride |
| Catalog No.GC62719 |
GSK2879552 dichlorhydrate un inhibiteur oral, sélectif et irréversible de la déméthylase spécifique de la lysine 1 (LSD1/KDM1A), avec une activité antinéoplasique potentielle.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1902123-72-1
Sample solution is provided at 25 µL, 10mM.
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GSK2879552 dihydrochloride an orally active, selective and irreversible inhibitor of lysine specific demethylase 1 (LSD1/KDM1A), with potential antineoplastic activity[1][2].
GSK2879552 inhibits KDM1A histone demethylase activity, inducing differentiation of sorafenib-resistant cells and attenuates stemness properties. GSK2879552 depresses the transcription of Wnt antagonists and downregulates β-catenin signaling activity in sorafenib-resistant cells[1].
GSK2879552 (1.5 mg/kg, p.o.) treatment exhibits tumor growth inhibition in SCLC xenograft bearing mice[2].
[1]. Huang M, et al. Targeting KDM1A attenuates Wnt/β-catenin signaling pathway to eliminate sorafenib-resistant stem-like cells in hepatocellular carcinoma. Cancer Lett. 2017 Apr 2;398:12-21.
[2]. Mohammad HP, et al. A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC. Cancer Cell. 2015 Jul 13;28(1):57-69.
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)
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