GSK2945 hydrochloride |
| Catalog No.GC39168 |
Le chlorhydrate de GSK2945 est une classe d'amine tertiaire et est un antagoniste hautement spécifique de Rev-erbα/REV-ERBα (virus de l'érythroblastose inverse de souris/humain α) avec des CE50 de 21,5 μM et 20,8 μM, respectivement.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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GSK2945 hydrochloride is a class of tertiary amine, and is a highly specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist with EC50s of 21.5 μM and 20.8 μM, respectively. GSK2945 hydrochloride enhances cholesterol 7α-hydroxylase (CYP7A1) level and cholesterol metabolism[1].
[1]. Zhang T, et al. REV-ERBα Regulates CYP7A1 Through Repression of Liver Receptor Homolog-1. Drug Metab Dispos. 2018 Mar;46(3):248-258.
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