Guangxitoxin 1E |
| Catalog No.GC50231 |
La guangxitoxine 1E est un bloqueur puissant et sélectif des canaux KV2.1 et KV2.2.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1233152-82-3
Sample solution is provided at 25 µL, 10mM.
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Kv2.1 and Kv2.2 channel blocker (IC50 values are 1-3 nM). Enhances glucose-stimulated insulin secretion from human islets in vitro, but not from islet cells lacking the Kv2.1 channel. Has no significant effect on plasma insulin, glucagon or blood glucose levels in mice, but increases plasma somatostatin levels.
Li et al (2013) The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of Ins and somatostatin release from pancreatic islets. J.Pharmacol.Exp.Ther. 344 407 PMID:23161216 |Herrington (2007) Gating modifier peptides as probes of pancreatic beta-cell physiology. Toxicon 49 231 PMID:17101164
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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