DHODH-IN-9 |
Catalog No.GC70740 |
DHODH-IN-9 (composé 10K), un analogue azoté, est un inhibiteur de la dihydrolactate déshydrogénase humaine.
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Cas No.: 1644156-41-1
Sample solution is provided at 25 µL, 10mM.
DHODH-IN-9 (Compound 10k) is a corresponding pyridazine homologue from 3-chloro-6-cyclopropylpyridazine. With few variations, the pattern of antiviral effect for analogues featuring a 5-cyclopylpyridine is somehow mirroring the one seen for the 5-ethylpyrimidyl bearing homologues. DHODH-IN-9 (Compound 10k) is a good antiviral of this group of analogue[1].
References:
[1]. Lucas-Hourani M, et al.Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH).J Med Chem. 2015 Jul 23;58(14):5579-98.
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