HMGB1-IN-1 |
| Catalog No.GC71351 |
HMGB1-IN-1 (composé 6) a montré une forte inhibition du No dans les cellules raw264.7 avec une IC50 de 15,9 ± 0,6 µm.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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HMGB1-IN-1 (compound 6) (0-30 μM, 0-48 h) not only decreases IL-1β and TNF-α levels in RAW264.7 cells and HK-2 cells, but also down-regulates the levels of NLRP3, P-NF-κB p65 and HMGB1 in activated HK-2 cells in a dose-dependent manner[1].
HMGB1-IN-1 (compound 6) (15-30 mg/kg, intraperitoneal injection) shows good anti-inflammatory activity[1].
References:
[1]. Qiang X, et al. Synthesis of glycyrrhizin analogues as HMGB1 inhibitors and their activity against sepsis in acute kidney injury. Eur J Med Chem. 2023 Nov 5;259:115696.
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