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ICA (N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine) (Synonyms: N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine)

Catalog No.GC32179

ICA (N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine) (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) est un Inhibiteur du canal SK qui a une activité antileishmanienne avec une IC50 de 2,1 μM.

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ICA (N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine) Chemical Structure

Cas No.: 3374-88-7

Taille Prix Stock Qté
10mM (in 1mL DMSO)
386,00 $US
En stock
1mg
138,00 $US
En stock
5mg
414,00 $US
En stock
10mg
689,00 $US
En stock
50mg
2 023,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC50 of 2.1 µM.

The SK channel inhibitor ICA exhibits antiarrhythmic effects. ICA prevents electrically induced runs of atrial fibrillation in the isolated right atrium and induces atrial postrepolarization refractoriness and depolarizes resting membrane potential. ICA at 1 to 10 μM slows conduction velocity. At increased pacing frequencies, SK channel inhibition by ICA (10-30 μM) demonstrates prominent depression of other sodium channel-dependent parameters[2].

[1]. Bhuniya D, et al. Aminothiazoles: Hit to lead development to identify antileishmanial agents. Eur J Med Chem. 2015 Sep 18;102:582-93. [2]. Skibsbye L, et al. Antiarrhythmic Mechanisms of SK Channel Inhibition in the Rat Atrium. J Cardiovasc Pharmacol. 2015 Aug;66(2):165-76.

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