Ipsapirone (hydrochloride) (Synonyms: TVXQ 7821) |
| Catalog No.GC91417 |
Ipsapirone est un agoniste partiel du récepteur de la sérotonine (5-HT) 5-HT1A (Ki = 10 nM dans les membranes hippocampiques).
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Cas No.: 92589-98-5
Sample solution is provided at 25 µL, 10mM.
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Ipsapirone is a partial agonist of the serotonin (5-HT) receptor 5-HT1A (Ki = 10 nM in hippocampal membranes).1 It reduces 5-HT release in rat ventral hippocampus in vivo.2 Low doses of ipsapirone decrease, while high doses increase, extracellular dopamine release in murine nucleus accumbens.3 Extracellular dopamine levels in murine striatum increase following administration of ipsapirone at concentrations >0.1 mg/kg. Ipsapirone has anxiolytic effects in vivo, inhibiting foot shock-induced aggression and passive avoidance behavior in rats (ED50s = 2.2 and 0.5 mg/kg, respectively).4 Formulations containing ipsapirone have been used to treat depression and borderline personality disorder.5
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