JP-1302 (hydrochloride) |
| Catalog No.GC43932 |
Le JP-1302 (chlorhydrate) est un antagoniste sélectif de haute affinité des récepteurs alpha2C-adrénergiques (α2C-adrénergiques), avec une valeur Kb (activité antagoniste) de 16 nM et une valeur Ki (affinité de liaison) de 28 nM.
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Cas No.: 1259314-65-2
Sample solution is provided at 25 µL, 10mM.
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JP-1302 is an antagonist of α2-adrenergic receptors (α2-ARs) that is selective for α2C-ARs over α2A- and α2B-ARs (Kis = 28, 3,150, and 1,470 nM, respectively). It reduces immobility time in the forced swim test in mice when administered at doses of 1, 3, and 10 µmol/kg. JP-1302 (5 mg/kg) reverses phencyclidine-induced decreases in prepulse inhibition of the acoustic startle response in rats. It dose-dependently reduces haloperidol-induced bradykinesia and catalepsy in mice. JP-1302 (0.3 mg/kg) also increases systolic blood pressure in rats.
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