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JQKD82 HCl (Synonyms: JQKD82 HCl; JQKD82 hydrochloride; JQKD82; JQKD-82; JQKD 82; PCK82; PCK-82; PCK 82;)

Catalog No.GB62209

JQKD82, also known as PCK82, is a cell-permeable and selective KDM5 inhibitor.

Products are for research use only. Not for human use. We do not sell to patients.

JQKD82 HCl Chemical Structure

Cas No.: 2410512-38-6

Taille Prix Stock Qté
1mg
150,00 $US
En stock
5mg
550,00 $US
En stock
10mg
950,00 $US
En stock
25mg
1 650,00 $US
En stock
50mg
2 950,00 $US
En stock
100mg
4 950,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Description of JQKD82 HCl

JQKD82, also known as PCK82, is a cell-permeable and selective KDM5 inhibitor (MM.1S cells, IC50 = 0.42 uM). JQKD82 increases histone H3K4me3 but paradoxically inhibits downstream MYC-driven transcriptional output in vitro and in vivo. JQKD82 is a useful tool compound to block KDM5A function as a potential therapeutic strategy for MM. QKD82 is a more stable ester of KDM5-C49 that is able to deliver the active molecule KDM5-C49 to cells more efficiently

Chemical Properties of JQKD82 HCl

Cas No. 2410512-38-6 SDF
Synonymes JQKD82 HCl; JQKD82 hydrochloride; JQKD82; JQKD-82; JQKD 82; PCK82; PCK-82; PCK 82;
Canonical SMILES O=C(OC1=CC=C(OC(C)C)C=C1OC(C)C)C2=CC=NC(CNCC(N(CCN(C)C)CC)=O)=C2.[H]Cl.[H]Cl.[H]Cl
Formula C27H43Cl3N4O5 M.Wt 610.01
Solubility To be determined Storage Store at-20℃
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of JQKD82 HCl

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1 mg 5 mg 10 mg
1 mM 1.6393 mL 8.1966 mL 16.3932 mL
5 mM 0.3279 mL 1.6393 mL 3.2786 mL
10 mM 0.1639 mL 0.8197 mL 1.6393 mL
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In vivo Formulation Calculator (Clear solution) of JQKD82 HCl

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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