K-Ras ligand-Linker Conjugate 3 |
| Catalog No.GC39190 |
K-Ras ligand-Linker Conjugate 3 (composé 001371) incorpore un ligand pour la fraction de recrutement de K-Ras et un lieur PROTAC, qui recrutent des ligases E3 (telles que VHL, CRBN, MDM2 et IAP). Le conjugué ligand K-Ras-Linker 3 peut être utilisé dans la synthèse de PROTAC K-Ras Degrader-1, qui est un puissant dégradeur PROTAC K-Ras qui présente une efficacité de dégradation ≥ 70 % dans les cellules SW1573.
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Cas No.: 2378261-87-9
Sample solution is provided at 25 µL, 10mM.
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K-Ras ligand-Linker Conjugate 3 (Compound 001371) incorporates a ligand for FAK (a KRas recruiting moiety), and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 3 can be extensively used for PROTAC-mediated protein degradation[1].
[1]. Andrew P. Crew, et al. Modulators of proteolysis and associated methods of use. WO2019195609A2.
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