KAT8-IN-1 |
| Catalog No.GC64990 |
KAT8-IN-1 est un inhibiteur de la lysine (K) acétyltransférase 8 (KAT8), avec des CI50 de 141 μM (KAT8), 221 μM (KAT2B), 106 μM (KAT3B), respectivement.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 605-62-9
Sample solution is provided at 25 µL, 10mM.
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KAT8-IN-1 is a lysine (K) acetyltransferase 8 (KAT8) inhibitor, with IC50s of 141 μM (KAT8), 221 μM (KAT2B), 106 μM (KAT3B), respectively. KAT8 inhibits histone acetyltransferases (HATs), and could result in disease states, such as cancer or inflammatory diseases[1].
KAT8-IN-1 (compound 19) losses anti-oxidant activity (EC50>1 mM)[1].
[1]. Wapenaar H, et al. The relevance of Ki calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor. Eur J Med Chem. 2017 Aug 18;136:480-486.
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