KL044 |
| Catalog No.GC63033 |
KL044, un stabilisateur de la protéine d'horloge cryptochrome (CRY), est une sonde chimique puissante avec une valeur de pEC50 de 7,32, conduisant À l'allongement de la période circadienne et À la répression de l'activité Per2.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1801856-93-8
Sample solution is provided at 25 µL, 10mM.
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KL044, a stabilizer of the clock protein cryptochrome (CRY) , is a potent chemical probe with a pEC50 value of 7.32, leading to the extension of the circadian period and repression of Per2 activity[1].
KL044 (0-3.7 μM; 8 h) effectively stabilizes the CRY1-LUC fusion protein without affecting the stability of LUC in the HEK293 stable cell line[1].
[1]. Jae Wook Lee, et al. Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock. ChemMedChem. 2015 Sep;10(9):1489-97.
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