KY-556 (N556) (Synonyms: N556) |
| Catalog No.GC31971 |
Le KY-556 (N556) est un promédicament prometteur et actif par voie orale du cromoglycate disodique (DSCG) contre les maladies allergiques.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 110816-78-9
Sample solution is provided at 25 µL, 10mM.
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KY-556 is a promising and orally-active pro-drug of disodium cromoglycate (DSCG) against allergic diseases.
The oral anti-allergic effect of KY-556 (N-556) is investigated. N-556 (10-100 mg/kg, p.o.) inhibits dose-dependently the 48-hr homologous passive cutaneous anaphylaxis (PCA) in rats, and the duration of action is longer than that of intravenous Disodium cromoglycate (DSCG). N-556 (20 and 100 mg/kg once a day for 20 consecutive days, p.o.) tends to inhibit the histamine release from actively sensitized rat lung fragments. N-556 (100 mg/kg, p.o.) shows the prolongation of survival time in the rat systemic anaphylaxis. N-556 (100 mg/kg, p.o.) significantly inhibits the increased airway resistance in experimental asthma in rats[1].
[1]. Nakamura S, et al. Effects of N-556 on experimental allergy models in rats. Arerugi. 1990 Dec;39(12):1621-8.
| Cas No. | 110816-78-9 | SDF | |
| Synonymes | N556 | ||
| Canonical SMILES | N[C@@H](CCCCN)C(OC(COC1=C2C(C=C(C(OCC)=O)OC2=CC=C1)=O)COC3=C4C(C=C(C(OCC)=O)OC4=CC=C3)=O)=O.[H]Cl.[H]Cl | ||
| Formula | C33H38Cl2N2O12 | M.Wt | 725.57 |
| Solubility | DMSO : 83.33 mg/mL (114.85 mM; Need ultrasonic) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.3782 mL | 6.8911 mL | 13.7823 mL |
| 5 mM | 0.2756 mL | 1.3782 mL | 2.7565 mL |
| 10 mM | 0.1378 mL | 0.6891 mL | 1.3782 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)
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