L-826,266 |
| Catalog No.GC44021 |
L-826,266 est un antagoniste sélectif et compétitif des récepteurs EP3.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 244101-03-9
Sample solution is provided at 25 µL, 10mM.
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L-826,266 is a potent and selective competitive antagonist of the prostaglandin E2 receptor subtype EP3 (Ki = 0.8 nM). It also binds to the EP4 receptor (Ki = 715 nM) but does not bind to EP1 or EP2 receptors up to a concentration of 5,000 nM. L-826,266 inhibits vasoconstriction induced by the EP3 agonist sulprostone in a concentration-dependent manner (EC50s = 0.45-24.5 µM in isolated human pulmonary arteries). It also inhibits sulprostone-induced norepinephrine and serotonin release in rat cortex and norepinephrine release in rat vas deferens (pA2s = 7.56, 7.67, and 7.87, respectively).
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)
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